IUBMB Enzyme Nomenclature


Accepted name: glutamate—cysteine ligase

Reaction: ATP + L-glutamate + L-cysteine = ADP + phosphate + γ-L-glutamyl-L-cysteine

For diagram of reaction click here.

Other name(s): γ-glutamylcysteine synthetase; γ-glutamyl-L-cysteine synthetase; γ-glutamylcysteinyl synthetase

Systematic name: L-glutamate:L-cysteine γ-ligase (ADP-forming)

Comments: Can use L-aminohexanoate in place of glutamate.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9023-64-7


1. Mackinnon, C.M., Carter, P.E., Smyth, S.J., Dunbar, B. and Fothergill, J.E. Molecular-cloning of cDNA for human-complement component c1s - the complete amino-acid sequence. Eur. J. Biochem. 169 (1987) 547-553.

2. Snoke, J.E., Yanari, S. and Bloch, K. Synthesis of glutathione from γ-glutamylcysteine. J. Biol. Chem. 201 (1953) 573-586.

3. Mandeles, S. and Bloch, K. Enzymatic synthesis of γ-glutamylcysteine. J. Biol. Chem. 214 (1955) 639-646.

[EC created 1961]

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