IUBMB Enzyme Nomenclature

EC 6.2.1.60

Accepted name: marinolic acid—CoA ligase

Reaction: (1) ATP + a marinolic acid + CoA = AMP + diphosphate + a marinoloyl-CoA
(2) ATP + a pseudomonic acid + CoA = AMP + diphosphate + a pseudomonoyl-CoA

Glossary: thiomarinols = natural products that combine monic acid and the compact holothin core of the dithiolopyrrolones.

Other name(s): tmlU (gene name)

Systematic name: marinolic acid:CoA ligase (AMP-forming)

Comments: The enzyme, characterized from the bacterium Pseudoalteromonas sp. SANK 73390, catalyses the CoA acylation of pseudomonic and marinolic acids, as part of the biosynthesis of thiomarinols and related compounds.

References:

1. Dunn, Z.D., Wever, W.J., Economou, N.J., Bowers, A.A. and Li, B. Enzymatic basis of "hybridity" in thiomarinol biosynthesis. Angew. Chem. Int. Ed. Engl. 54 (2015) 5137-5141. [PMID: 25726835]

[EC 6.2.1.60 created 2019]


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