Reaction: (1) ATP + a marinolic acid + CoA = AMP + diphosphate + a marinoloyl-CoA
(2) ATP + a pseudomonic acid + CoA = AMP + diphosphate + a pseudomonoyl-CoA
Glossary: thiomarinols = natural products that combine monic acid and the compact holothin core of the dithiolopyrrolones.
Other name(s): tmlU (gene name)
Systematic name: marinolic acid:CoA ligase (AMP-forming)
Comments: The enzyme, characterized from the bacterium Pseudoalteromonas sp. SANK 73390, catalyses the CoA acylation of pseudomonic and marinolic acids, as part of the biosynthesis of thiomarinols and related compounds.
1. Dunn, Z.D., Wever, W.J., Economou, N.J., Bowers, A.A. and Li, B. Enzymatic basis of "hybridity" in thiomarinol biosynthesis. Angew. Chem. Int. Ed. Engl. 54 (2015) 5137-5141. [PMID: 25726835]