IUBMB Enzyme Nomenclature


Accepted name: isophthalate—CoA ligase

Reaction: ATP + isophthalate + CoA = AMP + diphosphate + isophthalyl-CoA

Other name(s): IPCL

Systematic name: isophthalate:CoA ligase (AMP-forming)

Comments: The enzyme, characterized from the bacterium Syntrophorhabdus aromaticivorans, catalyses the first step in an anaerobic isophthalate degradation pathway.


1. Junghare, M., Spiteller, D. and Schink, B. Anaerobic degradation of xenobiotic isophthalate by the fermenting bacterium Syntrophorhabdus aromaticivorans. ISME J. 13 (2019) 1252-1268. [PMID: 30647456]

[EC created 2019]

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