IUBMB Enzyme Nomenclature


Accepted name: 6-carboxyhexanoate—CoA ligase

Reaction: ATP + 6-carboxyhexanoate + CoA = AMP + diphosphate + 6-carboxyhexanoyl-CoA

Other name(s): 6-carboxyhexanoyl-CoA synthetase; pimelyl-CoA synthetase

Systematic name: 6-carboxyhexanoate:CoA ligase (AMP-forming)

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 55467-50-0


1. Izumi, Y., Morita, H., Sato, K., Tani, Y. and Ogata, K. Synthesis of biotin-vitamers from pimelic acid and coenzyme A by cell-free extracts of various bacteria. Biochim. Biophys. Acta 264 (1972) 210-213. [PMID: 4623286]

2. Izumi, Y., Morita, H., Tani, Y. and Ogata, K. The pimelyl-CoA synthetase responsible for the first step in biotin biosynthesis by microorganisms. Agric. Biol. Chem. 38 (1974) 2257-2262.

[EC created 1983]

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