IUBMB Enzyme Nomenclature


Accepted name: acid—CoA ligase (GDP-forming)

Reaction: GTP + a carboxylate + CoA = GDP + phosphate + acyl-CoA

Other name(s): acyl-CoA synthetase (GDP-forming); acyl coenzyme A synthetase (guanosine diphosphate forming)

Systematic name: carboxylic acid:CoA ligase (GDP-forming)

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 37318-59-5


1. Rossi, C.R. and Gibson, D.M. Activation of fatty acids by a guanosine triphosphate-specific thiokinase from liver mitochondria. J. Biol. Chem. 239 (1964) 1694-1699. [PMID: 14213337]

[EC created 1972, modified 2011]

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