Reaction: ATP-dependent breakage, passage and rejoining of double-stranded DNA
Other name(s): type II DNA topoisomerase; DNA-gyrase; deoxyribonucleate topoisomerase; deoxyribonucleic topoisomerase; topoisomerase; DNA topoisomerase II
Systematic name: DNA topoisomerase (ATP-hydrolysing)
Comments: The enzyme can introduce negative superhelical turns into double-stranded circular DNA. One unit has nicking-closing activity, and another catalyses super-twisting and hydrolysis of ATP (cf. EC 188.8.131.52 DNA topoisomerase).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
1. Gellert, M. DNA topoisomerases. Annu. Rev. Biochem. 50 (1981) 879-910. [PMID: 6267993]