IUBMB Enzyme Nomenclature

EC 5.6.1.1

Accepted name: microtubule-severing ATPase

Reaction: n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) α/β tubulin heterodimers

Other name(s): katanin

Systematic name: ATP phosphohydrolase (tubulin-dimerizing)

Comments: A member of the AAA-ATPase family, active in splitting microtubules into tubulin dimers in the centrosome.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:

References:

1. McNally, F.J. and Vale, R.D. Identification of katanin, an ATPase that severs and disassembles stable microtubules. Cell 75 (1993) 419-429. [PMID: 8221885]

2. Hartman, J.J., Mahr, J., McNally, K., Okawa, K., Iwamatsu, A., Thomas, S., Cheesman, S., Heuser, J., Vale, R.D. and McNally, F.J. Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit. Cell 93 (1998) 277-287. [PMID: 9568719]

[EC 5.6.1.1 created 2000 as 3.6.4.3, transferred 2018 to EC 5.6.1.1]


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