IUBMB Enzyme Nomenclature

EC 5.3.3.22

Accepted name: lutein isomerase

Reaction: lutein = meso-zeaxanthin

For diagram of reaction click here.

Glossary: lutein = (3R,3'R)-dihydroxy-α-carotene
meso-zeaxanthin = (3R,3'S)-β,β-carotene-3,3'-diol

Other name(s): RPE65 (gene name); meso-zeaxanthin isomerase

Systematic name: lutein Δ45-isomerase

Comments: The enzyme is found in the retinal pigment epithelium (RPE) of vertebrates. It also has the activity of EC 3.1.1.64, retinoid isomerohydrolase.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:

References:

1. Shyam, R., Gorusupudi, A., Nelson, K., Horvath, M.P. and Bernstein, P.S. RPE65 has an additional function as the lutein to meso-zeaxanthin isomerase in the vertebrate eye. Proc. Natl Acad. Sci. USA 114 (2017) 10882-10887. [PMID: 28874556]

[EC 5.3.3.22 created 2018]


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