Reaction: 2-epi-5-epi-valiolone 7-phosphate = 5-epi-valiolone 7-phosphate
For diagram of reaction click here.
Glossary: 2-epi-5-epi-valiolone 7-phosphate = (2S,3S,4S,5R)-2,3,4,5-tetrahydroxy-5-(phosphonooxymethyl)cyclohexanone = (2S,3S,4S,5R)-2,3,4,5-tetrahydroxy-5-(phosphooxymethyl)cyclohexanone
5-epi-valiolone 7-phosphate = (2R,3S,4S,5R)-2,3,4,5-tetrahydroxy-5-(phosphonooxymethyl)cyclohexanone = (2R,3S,4S,5R)-2,3,4,5-tetrahydroxy-5-(phosphooxymethyl)cyclohexanone
Other name(s): AcbO
Systematic name: 2-epi-5-epi-valiolone-7-phosphate 2-epimerase
Comments: The enzyme, isolated from the bacterium Actinoplanes sp. SE 50/110, is involved in the biosynthesis of the α-glucosidase inhibitor acarbose.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
1. Zhang, C.S., Podeschwa, M., Altenbach, H.J., Piepersberg, W. and Wehmeier, U.F. The acarbose-biosynthetic enzyme AcbO from Actinoplanes sp. SE 50/110 is a 2-epi-5-epi-valiolone-7-phosphate 2-epimerase. FEBS Lett. 540 (2003) 47-52. [PMID: 12681481]