IUBMB Enzyme Nomenclature

EC 5.1.1.19

Accepted name: O-ureido-serine racemase

Reaction: O-ureido-L-serine = O-ureido-D-serine

Glossary: O-ureido-L-serine = (2S)-2-amino-3-[(carbamoylamino)oxy]propanoate
O-ureido-D-serine = (2R)-2-amino-3-[(carbamoylamino)oxy]propanoate

Other name(s): dcsC (gene name)

Systematic name: (2S)-2-amino-3-[(carbamoylamino)oxy]propanoate 2-epimerase

Comments: The enzyme employs a two-base mechanism, with a thiolate-thiol pair in the active site. It participates in the biosynthetic pathway of D-cycloserine, an antibiotic substance produced by several Streptomyces species.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:

References:

1. Kumagai, T., Koyama, Y., Oda, K., Noda, M., Matoba, Y. and Sugiyama, M. Molecular cloning and heterologous expression of a biosynthetic gene cluster for the antitubercular agent D-cycloserine produced by Streptomyces lavendulae. Antimicrob. Agents Chemother. 54 (2010) 1132-1139. [PMID: 20086163]

2. Dietrich, D., van Belkum, M.J. and Vederas, J.C. Characterization of DcsC, a PLP-independent racemase involved in the biosynthesis of D-cycloserine. Org. Biomol. Chem. 10 (2012) 2248-2254. [PMID: 22307920]

[EC 5.1.1.19 created 2013]


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