IUBMB Enzyme Nomenclature

EC 4.3.99.4

Accepted name: choline trimethylamine-lyase

Reaction: choline = trimethylamine + acetaldehyde

Other name(s): cutC (gene name)

Systematic name: choline trimethylamine-lyase (acetaldehyde-forming)

Comments: The enzyme utilizes a glycine radical to break the C-N bond in choline. Found in choline-degrading anaerobic bacteria.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:

References:

1. Craciun, S. and Balskus, E.P. Microbial conversion of choline to trimethylamine requires a glycyl radical enzyme. Proc. Natl. Acad. Sci. USA 109 (2012) 21307-21312. [PMID: 23151509]

[EC 4.3.99.4 created 2013]


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