Reaction: (2E,6E)-farnesyl diphosphate = (–)-α-cuprenene + diphosphate
For diagram of reaction click here.
Other name(s): Cop6
Systematic name: (–)-α-cuprenene hydrolase [cyclizing, (–)-α-cuprenene-forming]
Comments: The enzyme from the fungus Coprinopsis cinerea produces (–)-α-cuprenene with high selectivity.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:
References:
1. Lopez-Gallego, F., Agger, S.A., Abate-Pella, D., Distefano, M.D. and Schmidt-Dannert, C. Sesquiterpene synthases Cop4 and Cop6 from Coprinus cinereus: catalytic promiscuity and cyclization of farnesyl pyrophosphate geometric isomers. Chembiochem. 11 (2010) 1093-1106. [PMID: 20419721]