IUBMB Enzyme Nomenclature

EC 4.2.3.8

Accepted name: casbene synthase

Reaction: geranylgeranyl diphosphate = casbene + diphosphate

For reaction pathway click here.

Other name(s): casbene synthetase; geranylgeranyl-diphosphate diphosphate-lyase (cyclizing)

Systematic name: geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, CASbene-forming)

Comments: The enzyme from castor bean (Ricinus communis) produces the antifungal diterpene casbene.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 69106-45-2

References:

1. Moesta, P. and West, C.A. Casbene synthetase: regulation of phytoalexin biosynthesis in Ricinus communis L. seedlings. Purification of casbene synthetase and regulation of its biosynthesis during elicitation. Arch. Biochem. Biophys. 238 (1985) 325-333. [PMID: 3985625]

[EC 4.2.3.8 created 1989 as EC 4.6.1.7, transferred 2000 to EC 4.2.3.8]


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