IUBMB Enzyme Nomenclature

EC 4.2.3.182

Accepted name: pristinol synthase

Reaction: (2E,6E)-farnesyl diphosphate + H2O = (+)-(2S,3R,9R)-pristinol + diphosphate

For diagram of reaction click here and mechanism click here.

Glossary: (+)-(2S,3R,9R)-pristinol = (1R,6R,9aS)-1,4,8,8-tetramethyl-2,3,5,6,7,8,9,9a-octahydro-1H-cyclopenta[8]annulen-6-ol

Systematic name: (2E,6E)-farnesyl-diphosphate diphosphate-lyase [cyclizing, (+)-(2S,3R,9R)-pristinol-forming]

Comments: Isolated from the bacterium Streptomyces pristinaespiralis.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:

References:

1. Klapschinski, T.A., Rabe, P. and Dickschat, J.S. Pristinol, a sesquiterpene alcohol with an unusual skeleton from Streptomyces pristinaespiralis. Angew. Chem. Int. Ed. Engl. 55 (2016) 10141-10144. [PMID: 27403888]

[EC 4.2.3.182 created 2017]


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