IUBMB Enzyme Nomenclature

EC 4.2.3.115

Accepted name: α-terpinene synthase

Reaction: geranyl diphosphate = α-terpinene + diphosphate

For diagram of reaction click here.

Glossary: α-terpinene = 1-isopropyl-4-methylcyclohexa-1,3-diene

Systematic name: geranyl-diphosphate diphosphate-lyase (cyclizing, α-terpinene-forming)

Comments: The enzyme has been characterized from Dysphania ambrosioides (American wormseed). Requires Mg2+. Mn2+ is less effective. The enzyme will also use (3R)-linalyl diphosphate. The reaction involves a 1,2-hydride shift. The 1-pro-S hydrogen of geranyl diphosphate is lost.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:

References:

1. Poulose, A.J. and Croteau, R. γ-Terpinene synthetase: a key enzyme in the biosynthesis of aromatic monoterpenes. Arch. Biochem. Biophys. 191 (1978) 400-411. [PMID: 736574]

2. LaFever, R.E. and Croteau, R. Hydride shifts in the biosynthesis of the p-menthane monoterpenes α-terpinene, γ-terpinene, and β-phellandrene. Arch. Biochem. Biophys. 301 (1993) 361-366. [PMID: 8460944]

[EC 4.2.3.115 created 2012]


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