Reaction: geranyl diphosphate = (–)-sabinene + diphosphate
For diagram of reaction click here.
Glossary: (–)-sabinene = (1S,5S)-1-isopropyl-4-methylenebicyclo[3.1.0]hexane
Systematic name: geranyl-diphosphate diphosphate-lyase [cyclizing, (–)-sabinene-forming]
Comments: Requires Mg2+. Isolated from Pinus contorta (lodgepole pine) as cyclase I [1] and from Conocephalum conicum (liverwort) [2].
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:
References:
1. Savage, T.J., Hatch, M.W. and Croteau, R. Monoterpene synthases of Pinus contorta and related conifers. A new class of terpenoid cyclase. J. Biol. Chem. 269 (1994) 4012-4020. [PMID: 8307957]
2. Peters, R.J. and Croteau, R.B. Alternative termination chemistries utilized by monoterpene cyclases: chimeric analysis of bornyl diphosphate, 1,8-cineole, and sabinene synthases. Arch. Biochem. Biophys. 417 (2003) 203-211. [PMID: 12941302]