IUBMB Enzyme Nomenclature

EC 4.2.2.8

Accepted name: heparin-sulfate lyase

Reaction: Elimination of sulfate; appears to act on linkages between N-acetyl-D-glucosamine and uronate. Product is an unsaturated sugar.

Other name(s): heparin-sulfate eliminase; heparitin-sulfate lyase; heparitinase I; heparitinase II

Systematic name: heparin-sulfate lyase

Comments: Does not act on N,O-desulfated glucosamine or N-acetyl-O-sulfated glucosamine linkages.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 37290-86-1

References:

1. Hovingh, P. and Linker, A. The enzymatic degradation of heparin and heparitin sulfate. 3. Purification of a heparitinase and a heparinase from flavobacteria. J. Biol. Chem. 245 (1970) 6170-6175. [PMID: 5484472]

[EC 4.2.2.8 created 1972]


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