IUBMB Enzyme Nomenclature

EC 4.2.1.54

Accepted name: lactoyl-CoA dehydratase

Reaction: (R)-lactoyl-CoA = acryloyl-CoA + H2O

Other name(s): lactoyl coenzyme A dehydratase; lactyl-coenzyme A dehydrase; lactyl CoA dehydratase; acrylyl coenzyme A hydratase; lactoyl-CoA hydro-lyase

Systematic name: (R)-lactoyl-CoA hydro-lyase (acryloyl-CoA-forming)

Comments: A bacterial enzyme that is involved in propanoate fermentation (also known as the acrylate pathway).

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, UM-BBD, CAS registry number: 9031-12-3

References:

1. Baldwin, R.L., Wood, W.A. and Emery, R.S. Lactate metabolism by Peptostreptococcus elsdenii: evidence for lactyl coenzyme a dehydrase. Biochim. Biophys. Acta 97 (1965) 202-213. [PMID: 14292829]

2. Schweiger, G. and Buckel, W. On the dehydration of (R)-lactate in the fermentation of alanine to propionate by Clostridium propionicum. FEBS Lett 171 (1984) 79-84. [PMID: 6586495]

3. Kuchta, R.D. and Abeles, R.H. Lactate reduction in Clostridium propionicum. Purification and properties of lactyl-CoA dehydratase. J. Biol. Chem. 260 (1985) 13181-13189. [PMID: 4055736]

4. Kuchta, R.D., Hanson, G.R., Holmquist, B. and Abeles, R.H. Fe-S centers in lactyl-CoA dehydratase. Biochemistry 25 (1986) 7301-7307. [PMID: 3026450]

5. Hofmeister, A.E. and Buckel, W. (R)-lactyl-CoA dehydratase from Clostridium propionicum. Stereochemistry of the dehydration of (R)-2-hydroxybutyryl-CoA to crotonyl-CoA. Eur. J. Biochem. 206 (1992) 547-552. [PMID: 1597194]

[EC 4.2.1.54 created 1972, modified 2012]


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