Reaction: CDP-glucose = CDP-4-dehydro-6-deoxy-D-glucose + H2O
Other name(s): cytidine diphosphoglucose oxidoreductase; CDP-glucose 4,6-hydro-lyase
Systematic name: CDP-glucose 4,6-hydro-lyase (CDP-4-dehydro-6-deoxy-D-glucose-forming)
Comments: Requires bound NAD+.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 37259-55-5
References:
1. Hey, A.E. and Elbein, A.D. Biosynthesis of tyvelose. The purification and properties of cytidine diphosphate D-glucose oxidoreductase. J. Biol. Chem. 241 (1966) 5473-5478. [PMID: 4380946]
2. Matsuhashi, S., Matsuhashi, M., Brown, J.G. and Strominger, J.L. Enzymatic synthesis of cytidine diphosphate 3,6-dideoxyhexoses. 3. Cytidine diphosphate D-glucose oxidoreductase. J. Biol. Chem. 241 (1966) 4283-4287. [PMID: 4288651]
3. Melo, A., Elliott, H. and Glaser, L. The mechanism of 6-deoxyhexose synthesis. I. Intramolecular hydrogen transfer catalyzed by deoxythymidine diphosphate D-glucose oxidoreductase. J. Biol. Chem. 243 (1968) 1467-1474. [PMID: 4869560]