IUBMB Enzyme Nomenclature

EC 4.2.1.30

Accepted name: glycerol dehydratase

Reaction: glycerol = 3-hydroxypropanal + H2O

Other name(s): glycerol dehydrase; glycerol hydro-lyase

Systematic name: glycerol hydro-lyase (3-hydroxypropanal-forming)

Comments: Two different forms of the enzyme have been described. One form requires a cobamide coenzyme, while the other is a glycyl radical enzyme.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9077-68-3

References:

1. Smiley, K.L. and Sobolov, M. A cobamide-requiring glycerol dehydrase from an acrolein-forming Lactobacillus. Arch. Biochem. Biophys. 97 (1962) 538-543.

2. Schneider, Z. and Pawelkiewicz, J. The properties of glycerol dehydratase isolated from Aerobacter aerogenes, and the properties of the apoenzyme subunits. Acta Biochim. Pol. 13 (1966) 311-328. [PMID: 5962440]

3. Schneider, Z., Larsen, E.G., Jacobsen, G., Johnson, B.C. and Pawelkiewicz, J. Purification and properties of glycerol dehydrase. J. Biol. Chem. 245 (1970) 3388-3396. [PMID: 4989992]

4. Forage, R.G. and Foster, M.A. Glycerol fermentation in Klebsiella pneumoniae: functions of the coenzyme B12-dependent glycerol and diol dehydratases. J. Bacteriol. 149 (1982) 413-419. [PMID: 7035429]

5. O'Brien, J.R., Raynaud, C., Croux, C., Girbal, L., Soucaille, P. and Lanzilotta, W.N. Insight into the mechanism of the B12-independent glycerol dehydratase from Clostridium butyricum: preliminary biochemical and structural characterization. Biochemistry 43 (2004) 4635-4645. [PMID: 15096031]

[EC 4.2.1.30 created 1972]


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