IUBMB Enzyme Nomenclature

EC 4.2.1.103

Accepted name: cyclohexyl-isocyanide hydratase

Reaction: N-cyclohexylformamide = cyclohexyl isocyanide + H2O

Other name(s): isonitrile hydratase; N-cyclohexylformamide hydro-lyase

Systematic name: N-cyclohexylformamide hydro-lyase (cyclohexyl-isocyanide-forming)

Comments: The enzyme from Pseudomonas putida strain N19-2 can also catalyse the hydration of other isonitriles to the corresponding N-substituted formamides. The enzyme has no metal requirements.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, UM-BBD, CAS registry number: 358974-06-8

References:

1. Goda, M., Hashimoto, Y., Shimizu, S. and Kobayashi, M. Discovery of a novel enzyme, isonitrile hydratase, involved in nitrogen-carbon triple bond cleavage. J. Biol. Chem. 276 (2001) 23480-23485. [PMID: 11306561]

[EC 4.2.1.103 created 2001]


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