IUBMB Enzyme Nomenclature

EC 4.1.1.95

Accepted name: L-glutamyl-[BtrI acyl-carrier protein] decarboxylase

Reaction: L-glutamyl-[BtrI acyl-carrier protein] = 4-amino butanoyl-[BtrI acyl-carrier protein] + CO2

Other name(s): btrK (gene name)

Systematic name: L-glutamyl-[BtrI acyl-carrier protein] carboxy-lyase

Comments: Binds pyridoxal 5'-phosphate. Catalyses a step in the biosynthesis of the side chain of the aminoglycoside antibiotics of the butirosin family. Has very low activity with substrates not bound to an acyl-carrier protein.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:

References:

1. Li, Y., Llewellyn, N.M., Giri, R., Huang, F. and Spencer, J.B. Biosynthesis of the unique amino acid side chain of butirosin: possible protective-group chemistry in an acyl carrier protein-mediated pathway. Chem. Biol. 12 (2005) 665-675. [PMID: 15975512]

[EC 4.1.1.95 created 2012]


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