Reaction: 2-oxoglutarate = succinate semialdehyde + CO2
For diagram of reaction click here.
Glossary: thiamine diphosphate
Other name(s): oxoglutarate decarboxylase; α-ketoglutarate decarboxylase; α-ketoglutaric decarboxylase; oxoglutarate decarboxylase; pre-2-oxoglutarate decarboxylase; 2-oxoglutarate carboxy-lyase
Systematic name: 2-oxoglutarate carboxy-lyase (succinate-semialdehyde-forming)
Comments: Requires thiamine diphosphate. Highly specific.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 37205-42-8
References:
1. Shigeoka, S., Onishi, T., Maeda, K., Nakano, Y. and Kitaoka, S. Occurrence of thiamin pyrophosphate-dependent 2-oxoglutarate decarboxylase in mitochondria of Euglena gracilis. FEBS Lett. 195 (1986) 43-47.