IUBMB Enzyme Nomenclature

EC 3.8.1.9

Accepted name: (R)-2-haloacid dehalogenase

Reaction: (R)-2-haloacid + H2O = (S)-2-hydroxyacid + halide

Other name(s): 2-haloalkanoic acid dehalogenase[ambiguous]; 2-haloalkanoid acid halidohydrolase[ambiguous]; D-2-haloacid dehalogenase; D-DEX

Systematic name: (R)-2-haloacid halidohydrolase

Comments: Acts on acids of short chain lengths, C2 to C4, with inversion of configuration at C-2. [See also EC 3.8.1.2 (S)-2-haloacid dehalogenase, EC 3.8.1.10 2-haloacid dehalogenase (configuration-inverting) and EC 3.8.1.11 2-haloacid dehalogenase (configuration-retaining)]

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 119345-29-8

References:

1. Smith, J.M., Harrison, K. and Colby, J. Purification and characterization of D-2-haloacid dehalogenase from Pseudomonas putida strain AJ1/23. J. Gen. Microbiol. 136 (1990) 881-886. [PMID: 2380688]

2. Leigh, J.A., Skinner, A.J. and Cooper, R.A. Partial purification, stereospecificity and stoichiometry of three dehalogenases from a Rhizobium species. FEMS Microbiol. Lett. 49 (1988) 353-356.

3. Soda, K., Kurihara, T., Liu, J.-Q., Nardi-Dei, V., Park, C., Miyagi, M., Tsunasawa, S. and Esaki, N. Bacterial 2-haloacid dehalogenases: Structures and catalytic properties. Pure Appl. Chem. 68 (1996) 2097-2103.

[EC 3.8.1.9 created 2003]


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