IUBMB Enzyme Nomenclature

EC 3.6.5.6

Accepted name: tubulin GTPase

Reaction: GTP + H2O = GDP + phosphate

Systematic name: GTP phosphohydrolase (microtubule-releasing)

Comments: An intrinsic activity of α-tubulin involved in tubulin folding, division plane formation in prokaryotic cells and others.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:

References:

1. Yu, X.C. and Margolin, W. Ca2+-mediated GTP-dependent dynamic assembly of bacetrial cell division protein FtsZ into asters and polymer networks in vitro. EMBO J. 16, (1997) 5455-5463. [PMID: 9312004]

2. Tian, G., Bhamidipati, A., Cowan, N.J . and Lewis, S.A. Tubulin folding cofactors as GTPase-activating proteins. GTP hydrolysis and the assembly of the α/β-tubulin heterodimer. J. Biol. Chem. 274, (1999) 24054-24058. [PMID: 10446175]

3. Roychowdhury, S., Panda, D., Wilson, L. and Rasenick, M.M. G protein α subunits activate tubulin GTPase and modulate microtubule polymerization dynamics. J. Biol. Chem. 274, (1999) 13485-13490. [PMID: 10224115]

[EC 3.6.5.6 created 2000 as EC 3.6.1.51, transferred 2003 to EC 3.6.5.6]


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