Reaction: GTP + H2O = GDP + phosphate
Systematic name: GTP phosphohydrolase (microtubule-releasing)
Comments: An intrinsic activity of α-tubulin involved in tubulin folding, division plane formation in prokaryotic cells and others.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:
1. Yu, X.C. and Margolin, W. Ca2+-mediated GTP-dependent dynamic assembly of bacetrial cell division protein FtsZ into asters and polymer networks in vitro. EMBO J. 16, (1997) 5455-5463. [PMID: 9312004]
2. Tian, G., Bhamidipati, A., Cowan, N.J . and Lewis, S.A. Tubulin folding cofactors as GTPase-activating proteins. GTP hydrolysis and the assembly of the α/β-tubulin heterodimer. J. Biol. Chem. 274, (1999) 24054-24058. [PMID: 10446175]
3. Roychowdhury, S., Panda, D., Wilson, L. and Rasenick, M.M. G protein α subunits activate tubulin GTPase and modulate microtubule polymerization dynamics. J. Biol. Chem. 274, (1999) 13485-13490. [PMID: 10224115]