IUBMB Enzyme Nomenclature


Accepted name: arsenite-transporting ATPase

Reaction: ATP + H2O + arsenitein = ADP + phosphate + arseniteout

Systematic name: ATP phosphohydrolase (arsenite-exporting)

Comments: A multisubunit non-phosphorylated ATPase that is involved in the transport of ions. A bacterial enzyme that usually contains two subunits where one (with 12 membrane-spanning segments) forms the 'channel' part and the other (occurring in pairs peripherally to the membrane) contains the ATP-binding site. Exports arsenite and antimonite anions.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:


1. Silver, S., Misra, T.K. and Laddaga, R.A. DNA sequence analysis of bacterial toxic heavy metal resistance. Biol. Trace Elem. Res. 21 (1989) 145-163. [PMID: 2484581]

2. Rosen, B.P., Weigel, U., Monticello, R.A. and Edwards, B.P. Molecular analysis of an anion pump: purification of the ArsC protein. Arch. Biochem. Biophys. 284 (1991) 381-385. [PMID: 1703401]

3. Bruhn, D.F., Li, J., Silver, S., Roberto, F. and Rosen, B.P. The arsenical resistance operon of IncN plasmid R46. FEMS Microbiol. Lett. 139 (1996) 149-153. [PMID: 8674982]

4. Zhou, T., Rosen, B.P. and Gatti, D.L. Crystallization and preliminary X-ray analysis of the catalytic subunit of the ATP-dependent arsenite pump encoded by the Escherichia coli plasmid R773. Acta Crystallogr. D Biol. Crystallogr. 55 (1999) 921-924. [PMID: 10089335]

[EC created 2000]

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