IUBMB Enzyme Nomenclature

EC 3.6.1.66

Accepted name: XTP/dITP diphosphatase

Reaction: (1) XTP + H2O = XMP + diphosphate
(2) dITP + H2O = dIMP + diphosphate

Other name(s): hypoxanthine/xanthine dNTP pyrophosphatase; rdgB (gene name)

Systematic name: XTP/dITP diphosphohydrolase (diphosphate-forming)

Comments: The enzymes from the bacterium Escherichia coli and the archaea Methanococcus jannaschii and Archaeoglobus fulgidus are highly specific for XTP and dITP. The activity is dependent on divalent cations, Mg2+ is preferred.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:

References:

1. Chung, J.H., Back, J.H., Park, Y.I. and Han, Y.S. Biochemical characterization of a novel hypoxanthine/xanthine dNTP pyrophosphatase from Methanococcus jannaschii. Nucleic Acids Res. 29 (2001) 3099-3107. [PMID: 11452035]

2. Chung, J.H., Park, H.Y., Lee, J.H. and Jang, Y. Identification of the dITP- and XTP-hydrolyzing protein from Escherichia coli. J. Biochem. Mol. Biol. 35 (2002) 403-408. [PMID: 12297000]

[EC 3.6.1.66 created 2013]


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