Reaction: (1) P1,P6-bis(5'-adenosyl)hexaphosphate + H2O = 2 ATP
(2) P1,P5-bis(5'-adenosyl)pentaphosphate + H2O = ATP + ADP
(3) P1,P4-bis(5'-adenosyl)tetraphosphate + H2O = ATP + AMP
Other name(s): Ndx1
Systematic name: P1,P6-bis(5'-adenosyl)hexaphosphate nucleotidohydrolase (ATP-forming)
Comments: The enzyme requires the presence of the divalent cations (Mn2+, Mg2+, Zn2+, and Co2+). It hydrolyses P1,P4-bis(5-guanosyl) tetraphosphate very slowly [cf. EC 22.214.171.124, bis(5-nucleosyl)-tetraphosphatase (asymmetrical)].
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:
1. Iwai, T., Kuramitsu, S. and Masui, R. The Nudix hydrolase Ndx1 from Thermus thermophilus HB8 is a diadenosine hexaphosphate hydrolase with a novel activity. J. Biol. Chem. 279 (2004) 21732-21739. [PMID: 15024014]