IUBMB Enzyme Nomenclature


Accepted name: 2-nitroimidazole nitrohydrolase

Reaction: 2-nitroimidazole + H2O = imidazol-2-one + nitrite

Other name(s): NnhA; 2NI nitrohydrolase; 2NI denitrase

Systematic name: 2-nitroimidazole nitrohydrolase

Comments: The enzyme catalyses the initial step in the biodegradation of 2-nitroimidazole by the soil bacterium Mycobacterium sp. JS330

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Qu, Y. and Spain, J.C. Catabolic pathway for 2-nitroimidazole involves a novel nitrohydrolase that also confers drug resistance. Environ Microbiol 13 (2011) 1010-1017. [PMID: 21244596]

[EC created 2012]

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