IUBMB Enzyme Nomenclature

EC 3.5.99.5

Accepted name: 2-aminomuconate deaminase

Reaction: 2-aminomuconate + H2O = (3E)-2-oxohex-3-enedioate + NH3

Other name(s): amnD (gene name); nbaF (gene name)

Systematic name: 2-aminomuconate aminohydrolase

Comments: 2-Aminomuconate is an intermediate in the bacterial biodegradation of nitrobenzene. The enzyme has been isolated from several species, including Pseudomonas pseudocaligenes JS45, Pseudomonas fluorescens KU-7, Pseudomonas sp. AP3 and Burkholderia cenocepacia J2315. The reaction is spontaneous in acid conditions.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 201098-29-5

References:

1. He, Z and Spain, J.C. Studies of the catabolic pathway of degradation of nitrobenzene by Pseudomonas pseudoalcaligenes JS45: removal of the amino group from 2-aminomuconic semialdehyde. Appl. Environ. Microbiol. 63 (1997) 4839-4843. [PMID: 9471964]

2. He, Z. and Spain, J.C. A novel 2-aminomuconate deaminase in the nitrobenzene degradation pathway of Pseudomonas pseudoalcaligenes JS45. J. Bacteriol. 180 (1998) 2502-2506. [PMID: 9573204]

3. Takenaka, S., Murakami, S., Kim, Y.J. and Aoki, K. Complete nucleotide sequence and functional analysis of the genes for 2-aminophenol metabolism from Pseudomonas sp. AP-3. Arch. Microbiol. 174 (2000) 265-272. [PMID: 11081795]

4. Muraki, T., Taki, M., Hasegawa, Y., Iwaki, H. and Lau, P.C. Prokaryotic homologs of the eukaryotic 3-hydroxyanthranilate 3,4-dioxygenase and 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase in the 2-nitrobenzoate degradation pathway of Pseudomonas fluorescens strain KU-7. Appl. Environ. Microbiol. 69 (2003) 1564-1572. [PMID: 12620844]

[EC 3.5.99.5 created 2000, modified 2012]


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