IUBMB Enzyme Nomenclature

EC 3.5.3.25

Accepted name: Nω-hydroxy-L-arginine amidinohydrolase

Reaction: Nω-hydroxy-L-arginine + H2O = L-ornithine + hydroxyurea

Other name(s): dcsB (gene name)

Systematic name: Nω-hydroxy-L-arginine amidinohydrolase

Comments: The enzyme participates in the biosynthetic pathway of D-cycloserine, an antibiotic substance produced by several Streptomyces species.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:

References:

1. Kumagai, T., Koyama, Y., Oda, K., Noda, M., Matoba, Y. and Sugiyama, M. Molecular cloning and heterologous expression of a biosynthetic gene cluster for the antitubercular agent D-cycloserine produced by Streptomyces lavendulae. Antimicrob. Agents Chemother. 54 (2010) 1132-1139. [PMID: 20086163]

2. Kumagai, T., Takagi, K., Koyama, Y., Matoba, Y., Oda, K., Noda, M. and Sugiyama, M. Heme protein and hydroxyarginase necessary for biosynthesis of D-cycloserine. Antimicrob. Agents Chemother. 56 (2012) 3682-3689. [PMID: 22547619]

[EC 3.5.3.25 created 2013]


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