IUBMB Enzyme Nomenclature

EC 3.5.1.48

Accepted name: acetylspermidine deacetylase

Reaction: N8-acetylspermidine + H2O = acetate + spermidine

Glossary: spermidine
spermine

Other name(s): N8-monoacetylspermidine deacetylase; N8-acetylspermidine deacetylase; N-acetylspermidine deacetylase; N1-acetylspermidine amidohydrolase (incorrect)

Systematic name: N8-acetylspermidine amidohydrolase

Comments: It was initially thought that N1-acetylspermidine was the substrate for this deacetylase reaction [1] but this has since been disproved by Marchant et al. [3].

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 67339-07-5

References:

1. Libby, P.R. Properties of an acetylspermidine deacetylase from rat liver. Arch. Biochem. Biophys. 188 (1978) 360-363. [PMID: 28089]

2. Blankenship, J. Deacetylation of N8-acetylspermidine by subcellular fractions of rat tissue. Arch. Biochem. Biophys. 189 (1978) 20-27. [PMID: 708044]

3. Marchant, P., Manneh, V.A. and Blankenship, J. N1-Acetylspermidine is not a substrate for N-acetylspermidine deacetylase. Biochim. Biophys. Acta 881 (1986) 297-299. [PMID: 3955076]

[EC 3.5.1.48 created 1984, modified 2005]


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