IUBMB Enzyme Nomenclature

EC 3.5.1.128

Accepted name: deaminated glutathione amidase

Reaction: N-(4-oxoglutaryl)-L-cysteinylglycine + H2O = 2-oxoglutarate + L-cysteinylglycine

Glossary: N-(4-oxoglutaryl)-L-cysteinylglycine = deaminated glutathione

Other name(s): dGSH deaminase; NIT1 (gene name)

Systematic name: N-(4-oxoglutaryl)-L-cysteinylglycine amidohydrolase

Comments: The enzyme, present in animals, fungi and bacteria, is involved in clearing cells of the toxic compound deaminated glutathione, which can be produced as an unwanted side product by several transaminases.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:

References:

1. Peracchi, A., Veiga-da-Cunha, M., Kuhara, T., Ellens, K.W., Paczia, N., Stroobant, V., Seliga, A.K., Marlaire, S., Jaisson, S., Bommer, G.T., Sun, J., Huebner, K., Linster, C.L., Cooper, A.JL. and Van Schaftingen, E. Nit1 is a metabolite repair enzyme that hydrolyzes deaminated glutathione. Proc. Natl Acad. Sci. USA 114 (2017) E3233-E3242. [PMID: 28373563]

[EC 3.5.1.128 created 2018]


Return to EC 3.5.1 home page
Return to EC 3.5 home page
Return to EC 3 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page