Reaction: 2'''-acetyl-6'''-deamino-6'''-hydroxyneomycin C + H2O = 6'''-deamino-6'''-hydroxyneomycin C + acetate
For diagram of reaction click here.
Other name(s): neoL (gene name)
Systematic name: 2'''-acetyl-6'''-hydroxyneomycin C hydrolase (acetate-forming)
Comments: Involved in the biosynthetic pathway of aminoglycoside antibiotics of the neomycin family. The enzyme from the bacterium Streptomyces fradiae also catalyses EC 220.127.116.11, 2'-N-acetylparomamine deacetylase.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:
1. Yokoyama, K., Yamamoto, Y., Kudo, F. and Eguchi, T. Involvement of two distinct N-acetylglucosaminyltransferases and a dual-function deacetylase in neomycin biosynthesis. ChemBioChem. 9 (2008) 865-869. [PMID: 18311744]