IUBMB Enzyme Nomenclature

EC 3.4.24.82

Accepted name: ADAMTS-4 endopeptidase

Reaction: Glutamyl endopeptidase; bonds cleaved include -Thr-Glu-Gly-Glu373Ala-Arg-Gly-Ser- in the interglobular domain of mammalian aggrecan

Other name(s): aggrecanase-1

Comments: In peptidase family M12. Thought to be biologically significant for the degradation of the aggrecan component of cartilage matrix.

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, PDB, CAS registry number: 147172-61-0

References:

1. Westling, J., Fosang, A.J., Last, K., Thompson, V.P., Tomkinson, K.N., Hebert, T., McDonagh, T., Collins-Racie, L.A., LaVallie, E.R., Morris, E.A. and Sandy, J.D. ADAMTS4 cleaves at the aggrecanase site (Glu373-Ala374) and secondarily at the matrix metalloproteinase site (Asn341-Phe342) in the aggrecan interglobular domain. J. Biol. Chem. 277 (2002) 16059-16066. [PMID: 11854269]

[EC 3.4.24.82 created 2003]


Return to EC 3.4.24 home page
Return to EC 3.4 home page
Return to EC 3 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page