IUBMB Enzyme Nomenclature


Accepted name: gpr endopeptidase

Reaction: Endopeptidase action with P4 Glu or Asp, P1 preferably Glu > Asp, P1' hydrophobic and P2' Ala

Other name(s): germination proteinase

Comments: Initiates the degradation of small, acid-soluble proteins during spore germination in Bacillus megaterium. Type example of peptidase family M63.

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, PDB, CAS registry number: 75718-32-0


1. Ponnuraj, K., Rowland, S., Nessi, C., Setlow, P. and Jedrzejas, M.J. Crystal structure of a novel germination protease from spores of Bacillus megaterium: Structural arrangement and zymogen activation. J. Mol. Biol. 300 (2000) 1-10. [PMID: 10864493]

[EC created 2003]

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