IUBMB Enzyme Nomenclature


Accepted name: snapalysin

Reaction: Hydrolyses proteins with a preference for Tyr or Phe in the P1' position. Has no action on amino-acid p-nitroanilides

Other names: small neutral protease; SnpA gene product (Streptomyces lividans)

Comments: Type example of peptidase family M7.

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, PDB, CCAS registry number: 945859-47-2


1. Kurisu, G., Sugimoto, A., Harada, S., Takagi, M., Imanaka, T. and Kai, Y. Characterization of a small metalloprotease from Streptomyces caespitosus with high specificity to aromatic residues. J. Ferment. Bioeng. 83 (1997) 590-592.

2. Butler, M.J. Snapalysin. In: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (Eds.), Handbook of Proteolytic Enzymes, Academic Press, London, 1998, pp. 1134-1135.

3. Kurisu, G., Kai, Y. and Harada, S. Structure of the zinc-binding site in the crystal structure of a zinc endoprotease from Streptomyces caespitosus at 1 Å resolution. J. Inorg. Biochem. 82 (2000) 225-228. [PMID: 11132632]

[EC created 2001]

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