Val- bond in big endothelin to form endothelin 1
Reaction: Hydrolysis of the -Trp21Val- bond in big endothelin to form endothelin 1
Other name(s): endothelin-converting enzyme; ECE-1
Comments: A phosphoramidon-sensitive metalloendopeptidase In peptidase family M13 (neprilysin family). An integral membrane protein predominantly of endothelial cells, which generates the potent vasoconstrictor endothelin 1 from its inactive precursor
Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, PDB, CAS registry number: 138238-81-0
References
1. Takahashi, M., Matsushita, Y., Iijima, Y. and Tanzawa, K. Purification and characterization of endothelin-converting enzyme from rat lung. J. Biol. Chem. 268 (1993) 21394-21398. [PMID: 8407980]
2. Shimada, K., Takahashi, M. and Tanzawa, K. Cloning and functional expression of endothelin-converting enzyme from rat endothelial cells. J. Biol. Chem. 269 (1994) 18275-18278. [PMID: 8034569]
3. Xu, D., Emoto, N., Giaid, A., Slaughter, C., Kaw, S., DeWit, D. and Yanagisawa, M. ECE-1: A membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1. Cell 78 (1994) 473-485. [PMID: 8062389]