IUBMB Enzyme Nomenclature

EC 3.4.24.59

Accepted name: mitochondrial intermediate peptidase

Reaction: Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion

Other name(s): mitochondrial intermediate precursor-processing proteinase; MIP

Comments: A homologue of thimet oligopeptidase. Natural substrates are precursor proteins that have already been processed by mitochondrial processing peptidase. In peptidase family M3 (thimet oligopeptidase family)

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, CAS registry number: 136447-30-8

References

1. Isaya, G., Kalousek, F. and Rosenberg, L.E. Amino-terminal octapeptides function as recognition signals for the mitochondrial intermediate peptidase. J. Biol. Chem. 267 (1992) 7904-7910. [PMID: 1560019]

2. Isaya, G., Kalousek, F. and Rosenberg, L.E. Sequence analysis of rat mitochondrial intermediate peptidase: similarity to zinc metallopeptidases and to a putative yeast homologue. Proc. Natl. Acad. Sci. USA 89 (1992) 8317-8321. [PMID: 1518864]

[EC 3.4.24.59 created 1993]


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