Reaction: Specificity similar to, but narrower than, that of pepsin A. Does not cleave the Gln4-His bond in B chain of insulin
Comments: Occurs intracellularly, in lysosomes. A zymogen form is known . In peptidase family A1 (pepsin A family). Formerly EC 220.127.116.11
Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, PDB, CAS registry number: 9025-26-7
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3. Faust, P.L., Kornfeld, S. and Chirgwin, J.M. Cloning and sequence analysis of cDNA for human cathepsin D. Proc. Natl. Acad. Sci. USA 82 (1985) 4910-4914. [PMID: 3927292]
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