IUBMB Enzyme Nomenclature

EC 3.2.1.47

Accepted name: galactosylgalactosylglucosylceramidase

Reaction: α-D-galactosyl-(1→4)-β-D-galactosyl-(1→4)-β-D-glucosyl-(1↔1)-ceramide + H2O = D-galactose + β-D-galactosyl-(1→4)-β-D-glucosyl-(1↔1)-ceramide

For diagram of reaction click here.

Other name(s): trihexosyl ceramide galactosidase; ceramide trihexosidase; ceramidetrihexoside α-galactosidase; trihexosylceramide α-galactosidase; ceramidetrihexosidase

Systematic name: α-D-galactosyl-(1→4)-β-D-galactosyl-(1→4)-β-D-glucosyl-(1↔1)-ceramide galactohydrolase

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 9023-01-2

References:

1. Brady, R.O., Gal, A.E., Bradley, R.M. and Matensson, E. The metabolism of ceramide trihexosides. I. Purification and properties of an enzyme that cleaves the terminal galactose molecule of galactosylgalactosylglucosylceramide. J. Biol. Chem. 242 (1967) 1021-1026. [PMID: 6020428]

2. Mapes, C.A. and Sweeley, C.C. Substrate specificity of ceramide trihexosidase. FEBS Lett. 25 (1972) 279-281. [PMID: 11946769]

[EC 3.2.1.47 created 1972, modified 2011]


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