IUBMB Enzyme Nomenclature


Accepted name: isotuberculosinol synthase

Reaction: tuberculosinyl diphosphate + H2O = (13S)-isotuberculosinol + diphosphate

For diagram of reaction click here.

Glossary: tuberculosinyl diphosphate = halima-5,13-dien-15-yl diphosphate

Other name(s): Rv3378c

Systematic name: tuberculosinyl diphosphate diphosphohydrolase (isotuberculosinol forming)

Comments: Only found in species of Mycobacterium that cause tuberculosis. In addition, it also gives tuberculosinol in 1:1 mixture, cf EC, tuberculosinol synthase. The isotuberculosinol form was a 3:1 mixture of the 13S and1 3R forms, respectively.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Nakano, C., Ootsuka, T., Takayama, K., Mitsui, T., Sato, T. and Hoshino, T. Characterization of the Rv3378c gene product, a new diterpene synthase for producing tuberculosinol and (13R,S)-isotuberculosinol (nosyberkol), from the Mycobacterium tuberculosis H37Rv genome. Biosci. Biotechnol. Biochem. 75 (2011) 75-81. [PMID: 21228491]

2. Hoshino, T., Nakano, C., Ootsuka, T., Shinohara, Y. and Hara, T. Substrate specificity of Rv3378c, an enzyme from Mycobacterium tuberculosis, and the inhibitory activity of the bicyclic diterpenoids against macrophage phagocytosis. Org. Biomol. Chem. 9 (2011) 2156-2165. [PMID: 21290071]

[EC created 2011]

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