Reaction: 5"-phosphoribostamycin + H2O = ribostamycin + phosphate
For diagram of reaction click here.
Other name(s): btrP (gene name); neoI (gene name)
Systematic name: 5"-phosphoribostamycin phosphohydrolase
Comments: Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including ribostamycin, neomycin and butirosin. No metal is required for activity.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:
1. Kudo, F., Fujii, T., Kinoshita, S. and Eguchi, T. Unique O-ribosylation in the biosynthesis of butirosin. Bioorg. Med. Chem. 15 (2007) 4360-4368. [PMID: 17482823]