Reaction: myo-inositol hexakisphosphate + H2O = 1D-myo-inositol 1,2,3,5,6-pentakisphosphate + phosphate
Other name(s): 6-phytase (name based on 1L-numbering system and not 1D-numbering); phytase; phytate 6-phosphatase; myo-inositol-hexakisphosphate 6-phosphohydrolase (name based on 1L-numbering system and not 1D-numbering)
Systematic name: myo-inositol-hexakisphosphate 4-phosphohydrolase
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9001-89-2
References:
1. Johnson, L.F. and Tate, M.E. The structure of myo-inositol pentaphosphates. Ann. N.Y. Acad. Sci. 165 (1969) 526-532. [PMID: 4310376]
2. Tomlinson, R.V. and Ballou, C.E. Myoinositol polyphosphate intermediates in the dephosphorylation of phytic acid by phytase. Biochemistry 1 (1962) 166-171.
3. Lim, P.E. and Tate, M.E. The phytases. II. Properties of phytase fractions F1 and F2 from wheat bran and the myo-inositol phosphates produced by fraction F2. Biochim. Biophys. Acta 302 (1973) 316-328. [PMID: 4349266]
4. Cosgrove, D.J. Inositol phosphates: their chemistry, biochemistry, and physiology., Elsevier, Amsterdam, 1980