IUBMB Enzyme Nomenclature

EC 3.1.1.98

Accepted name: [Wnt protein] O-palmitoleoyl-L-serine hydrolase

Reaction: [Wnt]-O-(9Z)-hexadec-9-enoyl-L-serine + H2O = [Wnt]-L-serine + (9Z)-hexadec-9-enoate

Glossary: (9Z)-hexadec-9-enoate = palmitoleoate

Other name(s): Notum

Systematic name: [Wnt]-O-(9Z)-hexadec-9-enoyl-L-serine acylhydrolase

Comments: The enzyme removes the palmitoleate modification that is introduced to specific L-serine residues in Wnt proteins by EC 2.3.1.250, [Wnt protein]-O-palmitoleoyl transferase.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:

References:

1. Kakugawa, S., Langton, P.F., Zebisch, M., Howell, S.A., Chang, T.H., Liu, Y., Feizi, T., Bineva, G., O'Reilly, N., Snijders, A.P., Jones, E.Y. and Vincent, J.P. Notum deacylates Wnt proteins to suppress signalling activity. Nature (2015) . [PMID: 25731175]

[EC 3.1.1.98 created 2015]


Return to EC 3.1.1 home page
Return to EC 3.1 home page
Return to EC 3 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page