IUBMB Enzyme Nomenclature

EC 2.7.7.99

Accepted name: N-acetyl-α-D-muramate 1-phosphate uridylyltransferase

Reaction: UDP + N-acetyl-α-D-muramate 1-phosphate = UDP-N-acetyl-α-D-muramate + phosphate

Glossary: N-acetyl-D-muramate = 3-O-[(1R)-1-carboxyethyl]-2-acetoxy-2-deoxy-D-glucopyranose

Other name(s): murU (gene name)

Systematic name: UDP:N-acetyl-α-D-muramate 1-phosphate uridylyltransferase

Comments: The enzyme, characterized from Pseudomonas species, participates in a peptidoglycan salvage pathway.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:

References:

1. Gisin, J., Schneider, A., Nagele, B., Borisova, M. and Mayer, C. A cell wall recycling shortcut that bypasses peptidoglycan de novo biosynthesis. Nat. Chem. Biol. 9 (2013) 491-493. [PMID: 23831760]

2. Renner-Schneck, M., Hinderberger, I., Gisin, J., Exner, T., Mayer, C. and Stehle, T. Crystal structure of the N-acetylmuramic acid α-1-phosphate (MurNAc-α1-P) uridylyltransferase MurU, a minimal sugar nucleotidyltransferase and potential drug target enzyme in Gram-negative pathogens. J. Biol. Chem. 290 (2015) 10804-10813. [PMID: 25767118]

[EC 2.7.7.99 created 2017]


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