IUBMB Enzyme Nomenclature


Accepted name: 2-phospho-L-lactate guanylyltransferase

Reaction: (2S)-2-phospholactate + GTP = (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate

For diagram of reaction click here.

Glossary: (2S)-2-phospholactate = (2S)-2-(phosphonooxy)propanoate = (2S)-2-(phosphooxy)propanoate

Other name(s): CofC; MJ0887

Systematic name: GTP:2-phospho-L-lactate guanylyltransferase

Comments: This enzyme is involved in the biosynthesis of coenzyme F420, a redox-active cofactor found in all methanogenic archaea, as well as some eubacteria.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:


1. Grochowski, L.L., Xu, H. and White, R.H. Identification and characterization of the 2-phospho-L-lactate guanylyltransferase involved in coenzyme F420 biosynthesis. Biochemistry 47 (2008) 3033-3037. [PMID: 18260642]

[EC created 2010]

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