Reaction: nucleoside triphosphate + gentamicin = diphosphate + 2"-nucleotidylgentamicin
Other names: gentamicin 2"-adenylyltransferase; aminoglycoside adenylyltransferase; gentamycin 2"-nucleotidyltransferase
Systematic name: NTP:gentamicin 2"-nucleotidyltransferase
Comments: ATP, dATP, CTP, ITP and GTP can act as donors; kanamycin, tobramycin and sisomicin can also act as acceptors. The nucleotidyl residue is transferred to the 2-hydroxy of the 3-amino-3-deoxy-D-glucose moiety in the antibiotic.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 62213-33-6
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2. Naganawa, H., Yagisawa, M., Kondo, S., Takeuchi, T. and Umezawa, H. The structure determination of an enzymatic inactivation product of 3',4'-dideoxykanamycin B. J. Antibiot. 24 (1971) 913-914. [PMID: 4946513]
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