Reaction: ATP + [tyrosine-3-monooxygenase] = ADP + phospho-[tyrosine-3-monooxygenase]
Other name(s): pheochromocytoma tyrosine hydroxylase-associated kinase; STK4; tyrosine 3-monooxygenase kinase (phosphorylating)
Systematic name: ATP:[tyrosine-3-monoxygenase] phosphotransferase
Comments: The enzyme has no activating compound but is specific for its substrate, with which it co-purifies. Requires Mg2+. Activates EC 1.14.16.2, tyrosine 3-monooxygenase, by phosphorylation.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 103537-12-8
References:
1. Pigeon, D., Drissi-Daoudi, R., Gros, F. and Thibault, J. Copurification de la tyrosine hydroxylase due phéochromocytome de rat avec une protéine kinase. C.R. Acad. Sci. Paris III 302 (1986) 435-438. [PMID: 2872947]
2. Pigeon, D., Ferrara, P., Gros, F. and Thibault, J. Rat pheochromocytoma tyrosine hydroxylase is phosphorylated on serine 40 by an associated protein kinase. J. Biol. Chem. 262 (1987) 6155-6158. [PMID: 2883182]