IUBMB Enzyme Nomenclature

EC 2.7.1.78

Accepted name: polynucleotide 5'-hydroxyl-kinase

Reaction: ATP + 5'-dephospho-DNA = ADP + 5'-phospho-DNA

Other name(s): ATP:5'-dephosphopolynucleotide 5'-phosphatase; PNK; polynucleotide 5'-hydroxyl kinase (phosphorylating); 5'-hydroxyl polynucleotide kinase; 5'-hydroxyl polyribonucleotide kinase; 5'-hydroxyl RNA kinase; DNA 5'-hydroxyl kinase; DNA kinase; polynucleotide kinase; polynucleotide 5'-hydroxy-kinase

Systematic name: ATP:5'-dephosphopolynucleotide 5'-phosphotransferase

Comments: Also acts on 5'-dephospho-RNA 3'-mononucleotides.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 37211-65-7

References:

1. Novogrodsky, A. and Hurwitz, J. The enzymatic phosphorylation of ribonucleic acid and deoxyribonucleic acid. I. Phosphorylation at 5'-hydroxyl termini. J. Biol. Chem. 241 (1966) 2923-2932. [PMID: 4287929]

2. Novogrodsky, A., Tal, M., Traub, A. and Hurwitz, J. The enzymatic phosphorylation of ribonucleic acid and deoxyribonucleic acid. II. Further properties of the 5'-hydroxyl polynucleotide kinase. J. Biol. Chem. 241 (1966) 2933-2943. [PMID: 4287930]

[EC 2.7.1.78 created 1972]


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